Journal
NATURE IMMUNOLOGY
Volume 10, Issue 1, Pages 83-91Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1684
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [Di 764/2-2, GRK1104, SFB620]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007308] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The mucosal immune system of the intestine is separated from a vast array of microbes by a single layer of epithelial cells. Cues from the commensal microflora are needed to maintain epithelial homeostasis, but the molecular and cellular identities of these cues are unclear. Here we provide evidence that signals from the commensal microflora contribute to the differentiation of a lymphocyte population coexpressing stimulatory natural killer cell receptors and the transcription factor ROR gamma t that produced interleukin 22 ( IL-22). The emergence of these IL-22-producing ROR gamma t(hi)NKp46(+)NK1.1(int) cells depended on ROR gamma t expression, which indicated that these cells may have been derived from lymphoid tissue-inducer cells. IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available