Journal
NATURE IMMUNOLOGY
Volume 9, Issue 8, Pages 831-U16Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni0808-831
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Funding
- NIAID NIH HHS [U19 AI077437-019001, U19 AI077437, U19 AI077437-010001] Funding Source: Medline
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The production of inflammatory interleukin 1 beta after uptake of silica crystals and alum salt or amyloid-beta occurs by a process that involves lysosomal destabilization and release of cathepsin B that activates the NLRP3 inflammasome.
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