Journal
NATURE IMMUNOLOGY
Volume 10, Issue 1, Pages 75-82Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1681
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Funding
- Ligue Nationale contre le Cancer ('Equipe labellise e La Ligue')
- Agence Nationale de la Recherche
- Institut National de la Sante et de la Recherche Medicale
- Centre National de la Recherche Scientifique
- Ministere de l'Enseignement Superieur et de la Recherche
- Fondation pour la Recherche Medicale
- Region Provence Alpes Cote d'Azur-Institut National de la Sante et de la Recherche Medicale
- Crohn's and Colitis Foundation of America
- Institut Universitaire de France
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NKp46(+)CD3(-) natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-gamma. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46(+)CD3(-) cells with a diminished capacity to degranulate and produce interferon-gamma. In the gut, expression of the transcription factor ROR gamma t, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike ROR gamma t(-) lamina propria and dermis natural killer cells, gut ROR gamma t(+)NKp46(+) cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46(+)CD3(-) cells in innate immunity, lymphoid organization and local tissue repair.
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