Journal
NATURE IMMUNOLOGY
Volume 9, Issue 10, Pages 1165-1170Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1643
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Funding
- French Research Ministry
- Association pour la Recherche contre le Cancer
- Centre National de la Recherche Scientifique
- National Institutes of Health [5PO1-AI044220-09]
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In drosophila, molecular determinants from fungi and Gram-positive bacteria are detected by circulating pattern-recognition receptors. Published findings suggest that such pattern-recognition receptors activate as-yet-unidentified serine-protease cascades that culminate in the cleavage of Spatzle, the endogenous Toll receptor ligand, and trigger the immune response. We demonstrate here that the protease Grass defines a common activation cascade for the detection of fungi and Gram-positive bacteria mediated by pattern-recognition receptors. The serine protease Persephone, shown before to be specific for fungal detection in a cascade activated by secreted fungal proteases, was also required for the sensing of proteases elicited by bacteria in the hemolymph. Hence, Persephone defines a parallel proteolytic cascade activated by 'danger signals' such as abnormal proteolytic activities.
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