Journal
SKIN RESEARCH AND TECHNOLOGY
Volume 22, Issue 3, Pages 325-333Publisher
WILEY
DOI: 10.1111/srt.12265
Keywords
ethylhexyl dimethyl PABA; ethylhexyl methoxycinnamate; flavonoid; octocrylene; photoprotection; photostability
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Funding
- Sao Paulo Research Foundation (FAPESP) [2008/57800-0, 2010/10739-5]
- National Council of Technological and Scientific Development (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/10739-5] Funding Source: FAPESP
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Background/purpose: Ultraviolet (UV) radiation is responsible for sunburns, skin cancer, photoaging, and the production of reactive oxygen species (ROS). The awareness on preventing these deleterious effects made the use of anti-UVB formulations an important part of population habits; however, despite the availability of several antioxidants capable of ROS scavenging, the pharmaceutical market lacks products associating UV filters with natural compounds of proven efficacy. Here, we investigated the effect of rutin, a flavonoid with antioxidant activity, associated with UVB filters in dermocosmetic preparations. Methods: Formulations were assessed through its antioxidant activity, in vitro photoprotective effectiveness, photostability, and in vivo skin tolerance (hydration, transepidermal water loss, and erythema). Results: Samples containing rutin were compatible with the human skin and presented a pronounced antioxidant potential, with scavenging activity values 75% higher than the ones containing only UVB filters. Although rutin could not prevent the sunscreens photodegradation post-irradiation, the bioactive compound significantly increased the formulations critical wavelengths, showing a photoprotective gain, especially in the UVA range. Conclusion: In conclusion, the absorption in the UVA range, coupled with ROS scavenging potential, proved the positive effect of rutin applied to anti-UVB formulations, making this bioactive compound a promising candidate for photoprotection improvement.
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