Journal
NATURE GENETICS
Volume 46, Issue 11, Pages 1166-1169Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3096
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Funding
- IDEAS grant from Princess Margaret Hospital
- Head and Neck Translational Research Program
- Ontario Institute for Cancer Research
- government of Ontario
- Terry Fox Research Institute
- Wharton family, Joe's Team, Gordon Tozer
- Campbell Family Institute for Cancer Research
- Ministry of Health and Long-Term Planning, Canada
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Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
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