Journal
NATURE GENETICS
Volume 46, Issue 8, Pages 850-857Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3042
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Funding
- National Human Genome Research Institute (NHGRI) [U54 HG003273, U54 HG003079]
- US National Institutes of Health (NIH) [R01 DK077639, R01 GM59290, HG002385, P51-OD011133]
- National Science Foundation [NSF BCS-0751508]
- VEGA grant agency [1/0719/14, 1/1085/12]
- Howard Hughes Medical Institute grant
- NHGRI [K99 HG005846]
- Cullen Foundation
- European Research Council Starting Grant [260372]
- MICINN (Spain) [BFU2011-28549]
- Spanish National Institute of Bioinformatics
- ICREA Funding Source: Custom
- Austrian Science Fund (FWF) [P 24551] Funding Source: researchfish
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0845494] Funding Source: National Science Foundation
- Austrian Science Fund (FWF) [P24551] Funding Source: Austrian Science Fund (FWF)
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We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6x) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application.
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