Journal
NATURE GENETICS
Volume 45, Issue 5, Pages 501-U69Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2606
Keywords
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Funding
- Aarno Koskelo Foundation
- Agency for Science, Technology and Research of Singapore
- Australian National Health and Medical Research Council
- Australian Research Council
- BDA Research
- BioSHaRE Consortium
- British Heart Foundation
- Cedars-Sinai Board of Governors' Chair in Medical Genetics
- Centre for Clinical Research at the University of Leipzig
- Centre of Excellence in Genomics
- University of Tartu
- Chief Scientist Office of the Scottish government
- City of Kuopio
- Social Insurance Institution of Finland
- Department of Educational Assistance
- University and Research of the Autonomous Province of Bolzano
- Donald W. Reynolds Foundation
- Dutch Ministry for Health, Welfare and Sports
- Dutch Ministry of Education, Culture and Science
- Dutch BBRMI-NL
- Dutch Brain Foundation
- Dutch Centre for Medical Systems Biology
- Dutch Diabetes Research Foundation
- Dutch Government Economic Structure-Enhancing Fund
- Dutch Inter-University Cardiology Institute
- Dutch Kidney Foundation
- Dutch Ministry of Economic Affairs
- Dutch Ministry of Justice
- Dutch Research Institute for Diseases in the Elderly
- Eleanor Nichols endowments
- Emil Aaltonen Foundation
- Erasmus Medical Center
- Erasmus University
- Estonian government
- European Commission
- European Regional Development Fund
- European Research Council
- European Science Foundation
- Faculty of Biology and Medicine of Lausanne
- Finland's Slot Machine Association
- Finnish Cultural Foundation
- Finnish Diabetes Research Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Funding Agency for Technology and Innovation
- Finnish Heart Association
- Finnish Medical Society
- Finnish Ministry of Education and Culture
- Finnish Ministry of Health and Social Affairs
- Finnish National Institute for Health and Welfare
- Finnish Social Insurance Institution
- Finska Lakaresallskapet
- Folkhalsan Research Foundation
- Foundation for Life and Health in Finland
- French Ministry of Research
- French National Research Agency
- Genetic Association Information Network
- German Diabetes Association
- German Federal Ministry of Education and Research
- German Ministry of Cultural Affairs
- German National Genome Research Network
- German Research Foundation
- GlaxoSmithKline
- Goteborg Medical Society
- Greek General Secretary of Research and Technology
- Gyllenberg Foundation
- Health Care Centers in Vasa, Narpes and Korsholm
- Heinz Nixdorf Foundation
- Helmholtz Zentrum Munchen-German Research Center for Environmental Health
- Icelandic Heart Association
- Icelandic Parliament
- Intramural Research Program of the Division of Cancer Epidemiology and Genetics, the National Cancer Institute, NIH
- Italian Ministry of Education, Universities and Research
- Italian Ministry of Health
- Juho Vainio Foundation
- Juvenile Diabetes Research Foundation International
- Knut and Alice Wallenberg Foundation
- Kuopio, Tampere and Turku University Hospital Medical Funds
- Leducq Foundation
- Lundberg Foundation
- March of Dimes
- Munich Center of Health Sciences as part of LMUinnovativ
- Municipal Health Care Center and Hospital in Jakobstad
- Municipality of Rotterdam
- Narpes Health Care Foundation
- National Alliance for Research on Schizophrenia and Depression Young Investigator Awards
- Netherlands Genomics Initiative
- Netherlands Organization for Health Research and Development
- UK NHSBT
- US National Institutes of Health
- Nordic Center of Cardiovascular Research
- Nordic Center of Excellence in Disease Genetics
- Nordic Centre of Excellence on Systems Biology in Controlled Dietary Interventions and Cohort Studies
- Northern Netherlands Collaboration of Provinces
- Novo Nordisk Foundation
- Ollqvist Foundation
- Orion-Farmos Research Foundation
- Paavo Nurmi Foundation
- Paivikki and Sakari Sohlberg Foundation
- Perklen Foundation
- Petrus and Augusta Hedlunds Foundation
- Province of Groningen
- Republic of Croatia Ministry of Science, Education and Sport
- Reynold's Foundation
- Royal Society
- Samfundet Folkhalsan
- Signe and Ane Gyllenberg Foundation
- Sigrid Juselius Foundation
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Sophia Foundation for Medical Research
- South Tyrolean Sparkasse Foundation
- Southern California Diabetes Endocrinology Research Center
- Stockholm County Council
- Strategic Cardiovascular Program of Karolinska Institutet
- Strategic Support for Epidemiological Research at Karolinska Institutet
- Susan G. Komen Breast Cancer Foundation
- Swedish Ministry for Higher Education
- Swedish Cancer Society
- Swedish Cultural Foundation in Finland
- Swedish Diabetes Association
- Swedish Foundation for Strategic Research
- Swedish Heart-Lung Foundation
- Swedish Medical Research Council
- Swedish Ministry of Education
- Swedish Research Council
- Swedish Royal Academy of Science
- Swedish Society for Medical Research
- Swedish Society of Medicine
- Swiss National Science Foundation
- Tampere Tuberculosis Foundation
- Great Wine Estates of the Margaret River Region of Western Australia
- Paul Michael Donovan Charitable Foundation
- Torsten and Ragnar Soderberg Foundation
- Cancer Research UK
- UK Diabetes Association
- UK Heart Foundation
- UK MRCUK NIHR, Biomedical Research Centre
- UK West Anglia Primary and Community Care
- University Medical Center Groningen
- University of Groningen
- Vastra Gotaland Foundation
- VU University: the Institute for Health and Care Research and the Neuroscience Campus Amsterdam
- Wellcome Trust
- Yrjo Jahnsson Foundation
- Cancer Research UK [14136] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710] Funding Source: researchfish
- Economic and Social Research Council [ES/J023299/1, ES/G007438/1] Funding Source: researchfish
- Medical Research Council [MC_UU_12015/2, MC_U105260558, MC_U123092720, MR/K006584/1, G1000143, G0401527, G0601261, MC_UU_12015/1, MC_U106179472, G1002084, G0600237, G0801056B, MC_U106188470, MC_PC_U127561128, MR/K013351/1, G9521010, MC_U106179471] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0310-1002, NF-SI-0611-10099, NF-SI-0512-10113] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0005785] Funding Source: researchfish
- ESRC [ES/J023299/1, ES/G007438/1] Funding Source: UKRI
- MRC [MC_UU_12015/1, MR/K013351/1, G9521010, MC_U105260558, G1002084, MC_U106188470, MC_U106179472, MC_U123092720, G0601261, G0600237, MC_UU_12015/2, MC_PC_U127561128] Funding Source: UKRI
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Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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