Journal
NATURE GENETICS
Volume 45, Issue 7, Pages 831-U165Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2669
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Funding
- Office of Science of the DoE [DE-AC02-05CH11231]
- Max Planck Society
- Genome Quebec and Genome Canada VEGI grant
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Swedish Research Council
- Carl Trygger and Erik Philip-Sorensen foundations
- National Science Foundation (NSF) [0929262]
- French National Research Agency [ANR-08-KBBE-012-02]
- Czech Science Foundation [P501/12/G090]
- European Regional Development Fund [CZ.1.05/1.1.00/02.0068]
- Human Frontiers in Science Program Long-Term Fellowship
- Alfred P. Sloan Foundation
- Swedish National Infrastructure for Computing (SNIC) through the Uppsala Multidisciplinary Center for Advanced Computational Science UPPMAX) [b2012122]
- European Community [PIEF-GA-2008-221553]
- EMBO Long-Term fellowship
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0929262] Funding Source: National Science Foundation
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The shift from outcrossing to selfing is common in flowering plants(1,2), but the genomic consequences and the speed at which they emerge remain poorly understood. An excellent model for understanding the evolution of self fertilization is provided by Capsella rubella, which became self compatible <200,000 years ago. We report a C. rubella reference genome sequence and compare RNA expression and polymorphism patterns between C. rubella and its outcrossing progenitor Capsella grandiflora. We found a clear shift in the expression of genes associated with flowering phenotypes, similar to that seen in Arabidopsis, in which self fertilization evolved about 1 million years ago. Comparisons of the two Capsella species showed evidence of rapid genome-wide relaxation of purifying selection in C. rubella without a concomitant change in transposable element abundance. Overall we document that the transition to selfing may be typified by parallel shifts in gene expression, along with a measurable reduction of purifying selection.
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