Journal
NATURE GENETICS
Volume 45, Issue 12, Pages 1428-U171Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2800
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Funding
- US National Institutes of Health [R01CA169345, R01CA159467, R21CA143282]
- MD Anderson Cancer Center Bladder Cancer SPORE grant [P50CA091846]
- National Human Genome Research Institute, US National Institutes of Health
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Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
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