Journal
NATURE GENETICS
Volume 45, Issue 5, Pages 567-U150Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2604
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Funding
- US National Institutes of Health, National Center for Research Resources (NCRR)
- Office of Research Infrastructure Programs (ORIP), Division of Comparative Medicine [R24 RR024790, R24 OD011120]
- Deutsche Forschungsgemeinschaft [TRR 58/A5, TRR 17]
- Agence Nationale de Recherche
- [R24OD011199]
- [R24 RR032658]
- [R24 OD011198]
- [R01 RR020833]
- [R01 OD011116]
- [I/84 815]
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Several attributes intuitively considered to be typical mammalian features, such as complex behavior, live birth and malignant disease such as cancer, also appeared several times independently in lower vertebrates. The genetic mechanisms underlying the evolution of these elaborate traits are poorly understood. The platyfish, X. maculatus, offers a unique model to better understand the molecular biology of such traits. We report here the sequencing of the platyfish genome. Integrating genome assembly with extensive genetic maps identified an unexpected evolutionary stability of chromosomes in fish, in contrast to in mammals. Genes associated with viviparity show signatures of positive selection, identifying new putative functional domains and rare cases of parallel evolution. We also find that genes implicated in cognition show an unexpectedly high rate of duplicate gene retention after the teleost genome duplication event, suggesting a hypothesis for the evolution of the behavioral complexity in fish, which exceeds that found in amphibians and reptiles.
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