Journal
NATURE GENETICS
Volume 45, Issue 12, Pages 1504-U140Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2807
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Funding
- Chinese Academy of Sciences [XDA01020401]
- National Basic Research Program of China [2014CB965200, 2012CB966802, 2011CB965204]
- Guangdong Natural Science Funds for Distinguished Young Scholars [S2013050014040]
- National Natural Science Foundation of China [31271357, 31230039, 31221001, 91213304]
- Ministry of Science and Technology International Technology Cooperation Program [2012DFH30050]
- Science and Technology Planning Project of Guangdong Province [2011A060901019]
- National Science & Technology Major Special Project on Major New Drug Innovation [2011ZX09102-010]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Guangzhou Pearl River Nova program [2012J2200070]
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Vitamin C, a micronutrient known for its anti-scurvy activity in humans, promotes the generation of induced pluripotent stem cells (iPSCs)(1) through the activity of histone demethylating dioxygenases(2,3). TET hydroxylases are also dioxygenases implicated in active DNA demethylation(4-8). Here we report that TET1 either positively or negatively regulates somatic cell reprogramming depending on the absence or presence of vitamin C. TET1 deficiency enhances reprogramming, and its overexpression impairs reprogramming in the context of vitamin C-2,C-9 by modulating the obligatory mesenchymal-to-epithelial transition (MET)(10,11). In the absence of vitamin C, TET1 promotes somatic cell reprogramming independent of MET. Consistently, TET1 regulates 5-hydroxymethylcytosine (5hmC) formation at loci critical for MET in a vitamin C-dependent fashion. Our findings suggest that vitamin C has a vital role in determining the biological outcome of TET1 function at the cellular level. Given its benefit to human health, vitamin C should be investigated further for its role in epigenetic regulation.
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