Journal
NATURE GENETICS
Volume 45, Issue 10, Pages 1176-U311Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2744
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Funding
- MRC UK [U.1175.02.002.00015.01, U117581288]
- Swiss National Science Foundation [PP0033-119205]
- US National Institutes of Health [AI090928, HHSN266200700022C]
- Leverhulme-Royal Society Africa Award [AA080019]
- Natural Science Foundation of China [91231115]
- Wellcome Trust [098051]
- European Community (SysteMTb) [HEALTH-F4-2010-241587]
- European Union [272086]
- Ministerio de Economia y Competitividad (Spain) [BFU2011-24112]
- Medical Research Council [MC_U117588500, MC_U117581288] Funding Source: researchfish
- MRC [MC_U117588500, MC_U117581288] Funding Source: UKRI
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Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and to reconstruct the evolutionary history of this pathogen. Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period. This long coevolutionary history is consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
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