Journal
NATURE GENETICS
Volume 45, Issue 4, Pages 428-432Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2571
Keywords
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Categories
Funding
- European Commission under the 6th Framework Programme [LSHC-CT-2006-018702]
- Cancer Research UK Programme Awards [C588/A4994 and C588/A10589]
- Cancer Research UK [C8216/A6129]
- Leeds Cancer Research UK Centre [C37059/A11941]
- US National Institutes of Health (NIH [CA83115]
- intramural Research Program of the NIH
- US National Cancer Institute (NCI)
- Division of Cancer Epidemiology and Genetics
- Wellcome Trust [076113]
- Swedish Cancer Society
- Gunnar Nilsson Foundation
- European Research Council [ERC-2011-AdG 294576]
- Italian Ministry of Education, University and Research Progetti di Ricerca di Interesse Nazionale [2008W8JTPA_002]
- Intergruppo Melanoma Italian
- Mara Naum foundation
- INCa [INCa-PL016]
- Ligue Nationale Contre Le Cancer [PRE05/ FD, PRE 09/FD]
- Programme Hospitaller de Recherche Clinique [AOM-07-195]
- European Biobanking and Biomolecular Resources Research Infrastructure Netherlands hub [C018]
- Fond de Investigaciones Sanitarias, Spain [P.I. 09/01393]
- Centro de Investigaciones Biomedicas en Red (CIBER)
- Comprehensive Cancer Center, Oslo University Hospital [SE0728]
- Norwegian Cancer Society [71512-PR-2006-0356]
- Jubilaumsfonds of the Osterreichische Nationalbank [12161, 13036]
- Hans und Blanca Moser Stiftung
- NIH RO1 [CA65558-02]
- Department of Health and Human Services
- Intramural Research Program of NIH
- NCI Division of Cancer Epidemiology and Genetics
- NIH NCI [CA83115, P30CA023108, 2P50CA093459, CA88363, CAl22838, CA87969, CA055075, CA100264, CA133996, CA49449]
- Marit Peterson Fund for Melanoma Research
- Cancer Institute New South Wales
- National Health and Medical Research Council
- Dutch Cancer Society Koningin Wilhemina Fonds (KWF) Kankerbestrijding
- Radboud University Medical Centre
- Melanoma Research Alliance
- National Health and Medical Research Council of Australia (NHMRC) [200071, 241944, 339462, 380385, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496610, 496675, 496739, 552485, 552498]
- Cancer Councils New South Wales
- Victoria and Queensland
- Cooperative Research Centre for Discovery of Genes for Common Human Diseases (CRC)
- Cerylid Biosciences (Melbourne)
- Australian Cancer Research Foundation
- The Wellcome Trust [WT084766/Z/08/Z]
- NHMRC
- Career Development award from the NHMRC [496674, 613705]
- Cancer Australia [1011143]
- Cancer Research UK [10589] Funding Source: researchfish
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We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.
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