Journal
NATURE GENETICS
Volume 44, Issue 5, Pages 552-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2250
Keywords
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Categories
Funding
- Eli Lilly Company
- Wyeth
- Bristol-Myers Squibb
- AstraZeneca
- GlaxoSmithKline
- German Research Foundation
- Federal Ministry of Education and Research Germany
- Janssen-Cilag
- Novartis
- Lundbeck
- SALUS-Institute for Trend-Research and Therapy Evaluation in Mental Health
- Federal Ministry of Education and Research, Germany
- BioRad Laboratories
- Siemens AG
- Zeitschrift fur Laboratoriumsmedizin
- Bruker Daltronics
- Abbott
- Jurilab Kuopio
- Roche Diagnostics
- Instand
- Becton Dickinson
- Hofmann La Roche
- Humboldt Foundation
- Araclon
- Medivation/Pfizer
- Ipsen
- TauRx Therapeutics
- Bayer Healthcare
- Biogen Idec
- Exonhit Therapeutics
- SA
- Servier
- Synarc
- Pfizer
- Janssen
- Merck
- Avid
- DoD
- VA
- Alzheimer's Disease Neuroimaging Initiative
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Anonymous Foundation
- BioClinica (ADNI 2)
- Cure Alzheimer's Fund
- Eisai
- Elan
- Gene Network Sciences
- Genentech
- GE Healthcare
- Innogenetics
- Johnson Johnson
- Medpace
- Roche
- Schering Plough
- US NIH [U01 AG024904, U24 RR21992, MH0708143, MH083824, MH078111, MH59490, C06 RR13556, C06 RR017515, R01D0042157-01A, MH079799]
- Foundation for the NIH
- NIH [U01 AG024904, RC2 AG036535-01, P30 AG010129, K01 AG030514, EB006395, AG040060, EB008432, P41 RR013642, HD050735, AG036535, AG020098, EB008281]
- NIA [R01 AG019771-09]
- NCRAD [U24AG021886]
- ADNI (NIH) [U01 AG024904]
- NIA
- National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- Dana Foundation
- Biobanking and Biomolecular Resources Research Infrastructure Netherlands (BBMRI-NL)
- Netherlands Organisation for Scientific Research (NWO) [93511010]
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Health Foundation
- Italian Ministry of University and Research [RBIN04SWHR]
- European Commission [PL037286]
- UK Department of Health National Institute of Health Research (NIHR)-Biomedical Research Centre
- MRC [93558]
- NIA at the University of California, Los Angeles [AG16570]
- Age UK's Disconnected Mind programme
- Research Into Ageing [251, 285]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F019394/1]
- UK MRC [G1001401, 8200, G0901254]
- Engineering and Physical Sciences Research Council (EPSRC)
- Economic and Social Research Council (ESRC)
- Scottish Funding Council through the SINAPSE Collaboration
- AXA
- German Federal Ministry of Education and Research (BMBF)
- Exzellenz-Stiftung of the Max Planck Society
- BMBF in the framework of the National Genome Research Network (NGFN) [FKZ 01GS0481]
- Research Council of Norway [154313/ V50, 177458/V50, 167153/V50, 163070/V50, 183782/V50]
- Bergen Research Foundation
- University of Bergen
- Research Council of Norway (FUGE
- Psykisk Helse), Helse Vest Regionalt Helseforetak (RHF)
- Dr Einar Martens Fund
- NWO (MagW/ZonMW) [904-61-090, 985-10-002, 904-61-193, 480-04-004, 400-05-717, Addiction-31160008, 911-09-032, SPI 56-464-14192, 10-000-1002]
- Center for Medical Systems Biology (CMSB
- NWO Genomics)
- Biobanking and Biomolecular Resources Research Infrastructure
- VU University
- EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam
- European Science Foundation [EU/QLRT-2001-01254]
- European Community [HEALTH-F4-2007-201413]
- European Science Council (ERC) Genetics of Mental Illness [230374]
- Rutgers University Cell
- DNA Repository (NIMH) [U24 MH068457-06]
- Genetic Association Information Network (a public-private partnership between the NIH and Pfizer, Affymetrix and Abbott Laboratories)
- National Institute of Mental Health (NIMH) from NIH
- US Department of Health and Human Services [K99 MH085098, 1ZIA MH002810, 1ZIA MH002790]
- US National Institute of Child Health and Human Development [R01 HD050735]
- Australian National Health and Medical Research Council (NHMRC) [496682]
- NHMRC [389891, 613667]
- Australian Research Council (ARC) [FT0991634, FT110100548]
- Achievement Rewards for College Scientists foundation
- US NIMH [F31 MH087061, MH078075]
- National Science Foundation (NSF) [DGE-0707424]
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Quebec
- Canadian Foundation for Innovation
- German Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403]
- German Research Foundation (DFG) [GR 1912/5-1]
- Federal Ministry of Education and Research [03ZIK012, 03IS2061A]
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- German Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Simons Foundation
- Howard Hughes Medical Institute
- Oslo University Hospital-Ulleval
- Eastern Norway Health Authority [2004-123]
- Wellcome Trust [072894/z/03/z-Gill, 084730]
- Science Foundation Ireland [08/IN.1/B1916_Corvin, 08/RFP/GEN1538]
- University College London (UCL)/University College London Hospitals (UCLH) Comprehensive Biomedical Research Centre/Specialist Biomedical Research Centres (CBRC/SBRC) [114]
- European Union Marie Curie Reintegration
- UK NIHR [08-08-SCC]
- Comprehensive Local Research Network (CLRN) [CEL1300]
- The Big Lottery Fund
- Wolfson Trust
- Epilepsy Society
- UK Department of Health's NIHR Biomedical Research Centres
- Brainwave-the Irish Epilepsy Association
- Fonds National de la Recherche Scientifique [FC 63574 / 3.4.620.06 F]
- Fonds Erasme pour la Recherche Medicale at the Universite Libre de Bruxelles
- MRC Sudden Death Brain and Tissue Bank
- Sun Health Research Institute Brain Bank
- Netherlands Organization for Health Research and Development ZonMw [917.46.370]
- [NBIC/BioAssist/RK/2008.024]
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0901254, G0900908, G1001245, G0600429, G0802462, G0700704, G0901858, G1001401, G0701075] Funding Source: UKRI
- Science Foundation Ireland (SFI) [08/RFP/GEN1538] Funding Source: Science Foundation Ireland (SFI)
- Alzheimers Research UK [ART-PPG2011A-14] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Chief Scientist Office [SCD/10] Funding Source: researchfish
- Medical Research Council [G0901254, G0901858, G1001245, G0802462, G9817803B, G0600429, G0900908, G0700704, G0701075, G0801418B, G1001401] Funding Source: researchfish
- Australian Research Council [FT110100548] Funding Source: Australian Research Council
Ask authors/readers for more resources
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease(1,2) and is reduced in schizophrenia(3), major depression(4) and mesial temporal lobe epilepsy(5). Whereas many brain imaging phenotypes are highly heritable(6,7), identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 x 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 x 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 x 10(-7)).
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