Journal
NATURE GENETICS
Volume 44, Issue 3, Pages 307-U112Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.1087
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Funding
- US National Institutes of Health (NIH) [R01 CA064277, R37 CA070867, R01 CA090899, R01 CA118229, R01 CA092585, R01 CA122756]
- Ingram professorship funds
- Allen Foundation
- Vanderbilt Clinical and Translational Science Award (CTSA) [1 UL1 RR024975]
- National Center for Research Resources (NCRR) at NIH
- NIH [R01 CA064277, R01 CA118229, R01 CA092585, HL071981]
- Korea Centers for Disease Control and Prevention [4845-301, 4851-302, 4851-307]
- Biomedical Research Council of Singapore (BMRC) [05/1/36/19/413, 03/1/27/18/216]
- National Medical Research Council of Singapore (NMRC) [NMRC/1174/2008]
- NMRC [NMRC/CSA/008/2009, NMRC/0796/2003, NMRC/STaR/0003/2008, NMRC/0975/2005]
- Japan Science Technology Agency
- Program for Promotion of Fundamental Studies in Health Sciences
- National Institute of Biomedical Innovation Organization (NIBIO)
- National Center for Global Health and Medicine (NCGM)
- American Heart Association
- Boston Obesity Nutrition Research Center [DK46200]
- National Heart, Lung, and Blood Institute at NIH [HL072507, HL087263, HL090682]
- BMRC [06/1/21/19/466, 09/1/35/19/616, 08/1/35/19/550]
- Centre for Molecular Epidemiology at National University of Singapore
- Chinese National Key Program for Basic Research [973:2004CB518603]
- Chinese National High Tech Program [863:2009AA022703]
- National Cancer Institute (NCI) [CA063464, CA054281, CA132839]
- NIH Genes, Environment and Health Initiative (GEI) [HG004726]
- GEI [HG04424]
- Grants-in-Aid for Scientific Research [21390099, 21390209] Funding Source: KAKEN
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Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 x 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 x 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.
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