Journal
NATURE GENETICS
Volume 44, Issue 8, Pages 895-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2351
Keywords
-
Categories
Funding
- China National High-Tech Research and Development Program Grant [2009AA022705]
- National Key Basic Research Program Grant [2011CB503805]
- National Natural Science Foundation of China [30730080, 30972541, 30901233]
- Jiangsu Natural Science Foundation [BK2011028]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [11KJA330001]
- US National Institutes of Health Grant [U19 CA148127]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
To find additional susceptibility loci for lung cancer, we tested promising associations from our previous genome-wide association study (GWAS)(1) of lung cancer in the Chinese population in an extended validation sample size of 7,436 individuals with lung cancer (cases) and 7,483 controls. We found genome-wide significant (P < 5.0 x 10(-8)) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 x 10(-10)), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 x 10(-9)) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 x 10(-8)). We also found consistent associations for rs247008 at 5q31.1 (IL3-CSF2-P4HA2, P = 7.68 x 10(-8)) and rs9439519 at 1p36.32 (AJAP1-NPHP4, P = 3.65 x 10(-6)). Four of these loci showed evidence for interactions with smoking dose (P = 1.72 x 10(-10), P = 5.07 x 10(-3), P = 6.77 x 10(-3) and P = 4.49 x 10(-2) for rs2895680, rs4809957, rs247008 and rs9439519, respectively). These results advance our understanding of lung cancer susceptibility and highlight potential pathways that integrate genetic variants and smoking in the development of lung cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available