Journal
NATURE GENETICS
Volume 45, Issue 1, Pages 76-U115Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2477
Keywords
-
Categories
Funding
- Academy of Finland [126925, 121584, 124282, 129378, 117787, 41071, 209072, 129255, 104781, 120315, 129269, 1114194, 206374, 251360, 139900/24300796]
- Biocentrum Helsinki
- Arthritis Research UK
- Augustinus Foundation
- Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL)
- Biomedical Research Council, Singapore [BMRC 06/1/21/19/466]
- BIF: Boehringer Ingelheim Fonds
- British Heart Foundation
- C.G. Sundell Foundation
- Canadian Institutes of Health Research [MOP-82893]
- Cancer Research UK
- Chief Scientist Office of the Scottish Government
- Children's Hospital of Philadelphia (Institute Development Award)
- Conselleria de Sanitat Generalitat Valenciana
- Copenhagen Graduate School of Health Sciences
- Cotswold Foundation (Research Development Award)
- Curtin University and Women and Infants Research Foundation
- Danish Health Insurance Societies (Health Fund)
- Danish Medical Research Council
- Danish National Research Foundation
- Danish Pediatric Asthma Centre
- Danish Pharmacists' Fund
- Danish Strategic Research Council
- Darlington Trust
- Department of Health and Social Services in Northern Ireland
- Deutsche Forschungsgemeinschaft (DFG)
- Diabetes Hilfs-und Forschungsfonds Deutschland (DHFD)
- Diabetes UK [RD08/0003704, RD08/0003692]
- Dunhill Medical Trust
- Dutch Asthma Foundation [3.4.01.26, 3.2.06.022, 3.4.09.081, 3.2.10.085CO]
- Dutch Ministry of the Environment (EFRE)
- Europaische Fonds fur Regionale Entwicklung (LIFE Child Obesity)
- Egmont Foundation
- Else Kroner-Fresenius Foundation
- Emil Aaltonen Foundation
- ENGAGE project [HEALTH-F4-2007-201413]
- Erasmus Medical Center
- Erasmus University, Rotterdam
- European Commission [QLG1-CT-2000-01643, 018996, LSHG-CT-2006-018947, FOOD-CT-2005-007034]
- European Research Council (ERC Advanced) [230374]
- European Science Foundation (ESF) [EU/QLRT-2001-01254]
- Exeter NHS Research and Development
- Faculty of Biology and Medicine of Lausanne
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Finnish Innovation Fund Sitra
- Finnish Ministry of Education and Culture
- Finnish Ministry of Social Affairs and Health
- Finnish Social Insurance Institution
- Foundation for Paediatric Research
- Fundacio La Marato de TV3
- Fundacion Roger Torne
- Generalitat de Catalunya-Interminesterial Council for Research and Technological Innovation (CIRIT) [(1999SGR) 00241]
- German Diabetes Association
- German Bundesministerium fuer Forschung und Technology [01 AK 803 A-H, 01 IG 07015 G]
- German Research Foundation for the Clinical Research Group Atherobesity [KO3512/1]
- GlaxoSmithKline
- Hagedorn Research Institute
- Instituto de Salud Carlos III [CB06/02/0041, FIS PI041436, PI081151, PI041705, PS09/00432, FISFEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647]
- Interdisciplinary Centre for Clinical Research at the University of Leipzig [B27]
- Integrated Research and Treatment Centre (IFB) Adiposity Diseases
- Jackstadt-Foundation
- Juho Vainio Foundation
- Juvenile Diabetes Research Foundation International (JDRF)
- Kuopio, Tampere and Turku University Hospital Medical Funds [5031343, 9M048]
- Lundbeck Foundation
- Lundbeck Foundation Centre of Applied Medical Genomics for Personalized Disease Prediction, Prevention and Care (LuCAMP)
- March of Dimes Birth Defects Foundation [6-FY09-507]
- MRC, UK [74882, G0000934, G0601653, G0500539, G0600705, G0601261, G0600331, PrevMetSyn/SALVE PS0476, MC-A760-5QX00]
- Munich Center of Health Sciences (MC Health)
- National Health and Medical Research Council of Australia [403981, 003209]
- US National Human Genome Research Institute
- US National Institute of Allergy and Infectious Diseases
- US National Institute of Child Health and Human Development
- US National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- US National Institutes of Health [U01DK062418, U01HG004423, U01HG004446, U01HG004438, R01DK075787, 1R01HD056465-01A, R01D0042157-01A, DK078150, TW05596, HL085144, HD054501, RR20649, ES10126, DK56350]
- Netherlands Bioinformatics Centre (NBIC) BioAssist [RK/2008.024]
- National Heart, Lung, and Blood Institute (NHLBI) [5R01HL087679-02]
- National Heart, Lung, and Blood Institute (NHLBI) through the STAMPEED program [1RL1MH083268-01]
- NIH Genetic Association Information Network (GAIN)
- NIH/National Institute of Mental Health (NIMH) [5R01MH63706: 02, MH081802]
- Rutgers University Cell and DNA Repository cooperative agreement [NIMH U24 MH068457-06]
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Center for Medical Systems Biology (CMSB
- NWO Genomics)
- Netherlands Organization for Scientific Research (NWO: Social Sciences (MaGW)
- Netherlands Organization for Health Research and Development (ZonMw) [Middelgroot-911-09-032, Spinozapremie 56-464-14192, 904-61-090, 904-61-193, 480-04-004, 400-05-717, Addiction-31160008, 985-10-002, 40-005698- 9032, 912-03-031]
- Paavo Nurmi Foundation
- Peninsula NIHR Clinical Research Facility
- Pharmacy Foundation of 1991
- PhD School of Molecular Metabolism University of Southern Denmark
- Raine Medical Research Foundation
- Royal Society
- Sigrid Juselius Foundation
- South West NHS Research and Development
- Spanish Ministry of Science and Innovation [SAF2008-00357]
- Turku University Hospital
- Swiss National Science Foundation [33CSCO-122661]
- Tampere Tuberculosis Foundation
- Telethon Institute for Child Health Research
- Turku University Foundation
- US Centers for Disease Control and Prevention
- University Hospital Oulu, Biocenter, the University of Oulu [75617]
- University of Bristol
- University of Potsdam
- University of Southampton
- University of Western Australia (UWA)
- VU Institute for Health and Care Research (EMGO+)
- Neuroscience Campus Amsterdam (NCA)
- Wellcome Trust [GR069224, WT088806, 068545/Z/02, 076467, 085301, 090532, 083270, 083948, 085541/Z/08/Z, WT089549, WT083431MA]
- Yrjo Jahnsson Foundation
- Academy of Finland (Center of Excellence in Complex Disease Genetics)
- Academy of Finland (SALVE)
- British Heart Foundation [RG/07/009/23120] Funding Source: researchfish
- Diabetes UK [08/0003692] Funding Source: researchfish
- Medical Research Council [MC_U106188470, G0601653, G9815508, MC_U147585819, MC_U147585824, MC_U147585827, MC_UU_12011/4, MC_U106179471, MC_UP_A620_1017, MC_UU_12015/1, U1475000001, MC_U123292700, G0601261, MC_PC_U127561128, MC_UU_12011/1, MC_UU_12015/2, G0801056B, MC_UP_A620_1014, G0400491, MC_U106179472, G0600331, G0600705, MC_U123292701] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082, NF-SI-0611-10219, NF-SI-0611-10099] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710] Funding Source: researchfish
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R24HD050924, R01HD054501, R01HD056465] Funding Source: NIH RePORTER
- FOGARTY INTERNATIONAL CENTER [R01TW005596] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION [U22PS000476] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR020649] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL087679, R01HL085144] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG004446, U01HG004438, U01HG004423] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK056350, R01DK075787, R01DK078150, U01DK062418] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES010126] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH081802, U24MH068457, RL1MH083268, R01MH063706] Funding Source: NIH RePORTER
- MRC [G0601261, MC_UU_12015/1, G0400491, MC_UU_12015/2, MC_U106179472, MC_UU_12011/4, MC_U147585819, MC_U147585827, MC_U123292700, MC_PC_U127561128, MC_U123292701, G0600705, G0600331, MC_UP_A620_1017, G0601653, MC_U106188470] Funding Source: UKRI
Ask authors/readers for more resources
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
