Journal
NATURE GENETICS
Volume 44, Issue 3, Pages 260-U55Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.1051
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Funding
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: Medline
- Medical Research Council [MC_PC_U127592696, MC_PC_U127561128, MC_U127561128, G0700704, MC_U127592696, G0600705] Funding Source: Medline
- NCATS NIH HHS [UL1 TR000124] Funding Source: Medline
- NCI NIH HHS [P01 CA087969, R01 CA040356-15, U01 CA098233, R01 CA047988, U01 CA098233-01, P01 CA087969-12, R01 CA047988-09] Funding Source: Medline
- NHGRI NIH HHS [U01 HG004402-01, U01 HG004402] Funding Source: Medline
- NHLBI NIH HHS [U01 HL084756-01, R01 HL043851-09, U01 HL072515, N01 HC025195, N01 HC085086, R01 HL087660, R01 HL087660-01, N01 HC035129, N01 HC055015, U01 HL072515-01, R01 HL105756, R01 HL105756-01, N02 HL64278, U01 HL084756] Funding Source: Medline
- NIAAA NIH HHS [K05 AA017688] Funding Source: Medline
- NIAMS NIH HHS [R01 AR041398, R01 AR041398-09] Funding Source: Medline
- NIA NIH HHS [N01 AG012109, N01 AG012100, R21 AG032598-01, N01 AG050002, R21 AG032598] Funding Source: Medline
- NIDDK NIH HHS [P30 DK072488, P30 DK063491] Funding Source: Medline
- NIMHD NIH HHS [263 MD9164 13, 263 MD821336] Funding Source: Medline
- The Dunhill Medical Trust [R69/0208] Funding Source: Medline
- Chief Scientist Office [CZB/4/710] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710] Funding Source: researchfish
- Medical Research Council [G0600705, G0700704B, MC_U127561128, G0700704, MC_PC_U127592696, MC_U127592696, MC_PC_U127561128] Funding Source: researchfish
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [MC_U127561128, G0600705, MC_PC_U127592696, MC_PC_U127561128, G0700704, MC_U127592696] Funding Source: UKRI
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To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 x 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-kappa B signaling and mitochondrial dysfunction as biological processes related to timing of menopause.
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