Journal
NATURE GENETICS
Volume 44, Issue 6, Pages 681-U100Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2251
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Funding
- Wellcome Trust Case Control Consortium 3 (WTCCC3) initiative [088804/Z/09/Z]
- National Cancer Institute at the US National Institutes of Health [U10 CA98543, U10 CA98413, U24 CA114766]
- Cancer Research UK [C8620/A9024, C8620_A8857]
- UK Department of Health
- National Cancer Intelligence Network
- Scottish Government
- Children with Cancer UK
- NHS
- Michael and Betty Kadoorie Cancer Genetics
- Rosetrees Trust [M28-F1-CD2] Funding Source: researchfish
- Wellcome Trust [088804/Z/09/Z] Funding Source: Wellcome Trust
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Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 x 10(-5) in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 x 10(-14); rs807624, P = 1.32 x 10(-14)) and 11q14 (rs790356, P = 4.25 x 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22.
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