Journal
NATURE GENETICS
Volume 44, Issue 4, Pages 426-U234Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.1104
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Funding
- BioBank Japan Project
- Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan
- Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government
- Japan Society for the Promotion of Science [22390306]
- Princess Takamatsu Cancer Research Fund
- Takeda Science Foundation
- US National Institutes of Health (NIH) [HG004726, CA148537, CA54281, CA63464]
- Grants-in-Aid for Scientific Research [10J02102, 23791782, 22240090, 22116010, 22390302, 22134002, 22390306] Funding Source: KAKEN
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We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10(-8)) and 3p11.2 (rs2055109; P = 3.94 x 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
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