Journal
NATURE GENETICS
Volume 44, Issue 12, Pages 1382-1387Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2452
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [Klinische Forschergruppe (KFO) 201]
- March of Dimes
- US National Institutes of Health (NIH) [1R01DK080004]
- UT Southwestern O'Brien Kidney Research Foundation [NIH P30DK079328]
- Excellence Initiative of the German Federal and State Governments [EXC 294-BIOSS]
- NIH/National Institute of General Medical Sciences (NIGMS)
- March of Dimes, the Burroughs Wellcome Fund
- UT Southwestern O'Brien Kidney Research Center [NIH P30DK079328]
- DFG [KFO 201]
- European Community [241955]
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Cystic kidney diseases are a global public health burden, affecting over 12 million people(1). Although much is known about the genetics of kidney development and disease, the cellular mechanisms driving normal kidney tubule elongation remain unclear(2,3). Here, we used in vivo imaging to show for the first time that mediolaterally oriented cell intercalation is fundamental to vertebrate kidney morphogenesis. Unexpectedly, we found that kidney tubule elongation is driven in large part by a myosin-dependent, multicellular rosette based mechanism, previously only described in Drosophila melanogaster. In contrast to findings in Drosophila, however, non-canonical Wnt and planar cell polarity (PCP) signaling is required to control rosette topology and orientation during vertebrate kidney tubule elongation. These data resolve long-standing questions concerning the role of PCP signaling in the developing kidney and, moreover, establish rosette-based intercalation as a deeply conserved cellular engine for epithelial morphogenesis.
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