Journal
NATURE GENETICS
Volume 44, Issue 8, Pages 900-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2353
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Funding
- Ministry of Health, Labor and Welfare for Research on Applying Health Technology and for the 3rd-term Comprehensive 10-year Strategy for Cancer Control
- Ministry of Education, Culture, Sports, Science and Technology of Japan for Scientific Research on Innovative Areas [22131006]
- Japan Society for the Promotion of Science for Research Activity Start-up [23800073]
- Young Scientists (B) [24790340]
- National Cancer Center Research and Development Fund
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- National Cancer Center Research and Development Fund, Japan
- Grants-in-Aid for Scientific Research [23650624, 22131006, 23800073, 22116010, 24790340] Funding Source: KAKEN
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Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P-combined = 2.8 x 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P-combined = 6.9 x 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P-combined = 7.4 x 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P-combined = 2.7 x 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
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