Journal
NATURE GENETICS
Volume 44, Issue 12, Pages 1330-1335Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2456
Keywords
-
Categories
Funding
- US National Institutes of Health/National Cancer Institute
Ask authors/readers for more resources
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer' cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 x 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 x 10(-18)), 6q22.2 (rs9387478, P = 4.14 x 10(-10)) and 6p21.32 (rs2395185, P = 9.51 x 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available