Journal
NATURE GENETICS
Volume 43, Issue 6, Pages 530-U57Publisher
NATURE PORTFOLIO
DOI: 10.1038/ng.834
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Funding
- Japan Science Technology Agency
- National Institute of Biomedical Innovation Organization (NIBIO)
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- National Center for Global Health and Medicine (NCGM)
- National Heart, Lung, and Blood Institute, National Institutes of Health (Bethesda, Maryland, USA) [U01HL072507, R01HL087263, R01HL090682]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (Bethesda, Maryland, USA) [K12HD043451]
- Korea Centers for Disease Control & Prevention, Republic of Korea [4845-301, 4851-302, 4851-307]
- Chinese National Key Program for Basic Research [2004CB518603, 2006CB503804, 2009CB521905]
- Chinese National High Tech Program [2009AA022703, 2006AA02Z179]
- Ministry of Science and Technology, National Natural Science Foundation [30871361]
- National Medical Research Council [NMRC 0796/2003, NMRC/STaR/0003/2008, NMRC/CSA/008/2009]
- Biomedical Research Council (BMRC) [09/1/35/19/616]
- Biomedical Research Council of Singapore [BMRC 05/1/36/19/413, 03/1/27/18/216]
- National Medical Research Council of Singapore [NMRC/1174/2008]
- Singapore National Research Foundation [NRF-RF-2010-05]
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Ministry of Health, Labor and Welfare, Health and Labor Sciences Research Grants, Japan [H15-longevity-005, H17-longevity-003, H16-kenko-001, H18-longevity (kokusai)]
- Japan Atherosclerosis Prevention Fund
- Academia Sinica Genomic Medicine Multicenter Study
- National Science Council, Taiwan (National Clinical Core) [NSC97-3112-B-001-014]
- National Science Council, Taiwan (National Genotyping Center) [NSC97-3112-B-001-015]
- Grants-in-Aid for Scientific Research [21390209, 20256001, 20390185, 22133003, 23710228] Funding Source: KAKEN
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We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 x 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 x 10(-31) and P = 1.3 x 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.
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