Journal
NATURE GENETICS
Volume 43, Issue 10, Pages 1005-U122Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.922
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Funding
- US National Institutes of Health
- National Heart, Lung, and Blood Institute, European
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [MC_U106188470, G0601966, MC_U127561128, G0801056, MC_U137686857, G0700931, G0701863, MC_PC_U127592696, G0902313, MC_PC_U127561128, G0700704, G9521010, MC_U127592696] Funding Source: UKRI
- Austrian Science Fund (FWF) [P 20545] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Chief Scientist Office [CZB/4/505, ETM/55, CZB/4/710] Funding Source: researchfish
- Kidney Research UK [RP24/2/2006] Funding Source: researchfish
- Medical Research Council [G0700704B, G0801056, MC_U127561128, G9521010, G0700931, G0902313, MC_U127592696, MC_U137686857, G1000143, MC_PC_U127561128, MC_PC_U127592696, MC_U106179471, MC_U106188470, G0801056B, G0601966, G0701863, G0700704, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0507-10315] Funding Source: researchfish
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Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
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