Journal
NATURE GENETICS
Volume 43, Issue 10, Pages 940-U40Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.920
Keywords
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Categories
Funding
- US National Institutes of Health (NIH) [N01-AG-12100]
- National Institute on Aging (NIA) Intramural Research Program
- Hjartavernd (the Icelandic Heart Association)
- Althingi (the Icelandic Parliament)
- NIH [R01 AG18728, R01 HL088119, U01 GM074518-04, U01 HL072515-06]
- University of Maryland General Clinical Research Center [M01 RR 16500]
- Baltimore Veterans Administration Medical Center Geriatrics Research and Education Clinical Center
- Paul Beeson Physician Faculty Scholars in Aging Program
- National Heart, Lung, and Blood Institute [N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, R01HL087641, R01HL59367, R01HL086694]
- National Human Genome Research Institute [U01HG004402]
- US National Institutes of Health [HHSN268200625226C, UL1RR025005]
- NIH Roadmap for Medical Research
- Netherlands Organisation for Scientific Research
- Erasmus Medical Center
- Centre for Medical Systems Biology (CMSB)
- National Heart, Lung, and Blood Institute (NHLBI) [N01-HC-85239, N01-HC-85079, N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, HL080295, HL075366, HL087652, HL105756]
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute of Aging [AG-023629, AG-15928, AG-20098, AG-027058, AG08122, AG16495, AG033193]
- National Center for Research Resources [M01RR00069]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK063491]
- National Heart, Lung, and Blood Institute's Framingham Heart Study [N01-HC-25195]
- Affymetrix, Inc. [N02-HL-6-4278]
- National Institute of Neurological Disorders and Stroke [NS17950]
- Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center
- Netherlands Organisation of Scientific Research (NWO, De Nederlandse Organisatie voor Wetenschappelijk Onderzoek) [175.010.2005.011, 911-03-012]
- Research Institute for Diseases in the Elderly [014-93-015, RIDE2]
- Netherlands Genomics Initiative (NGI)/Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]
- NWO [918-76-619]
- Erasmus Medical Center and Erasmus University
- Rotterdam
- Netherlands Organization for the Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- German Bundesministeriumfuer Forschung und Technology [01 AK 803 A-H, 01 IG 07015 G]
- National Institute on Aging, NIH
- National Institute on Aging [NO1-AG-1-2109]
- National Institute on Aging to the University of Michigan [263-MA-410953]
- National Institutes of Health [HG005581, HL084729]
- Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK012]
- Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- Austrian Science Fond (FWF) [P20545-P05, P13180]
- Medical University of Graz
- European Community [201668]
- government of Rheinland-Pfalz ('Stiftung Rheinland Pfalzfur Innovation') [AZ 961-386261/733]
- Wissenschafft Zukunft
- 'Schwerpunkt Vaskulare Pravention' of the Johannes Gutenberg-University of Mainz
- BoehringerIngelheim
- Philips Medical Systems
- Gutenberg Heart Study
- National Genome Network 'NGFNplus' [A3 01GS0833]
- Federal Ministry of Education and Research, Germany
- Helmholtz Zentrum Munchen
- German Research Center for Environmental Health, Neuherberg, Germany
- German Federal Ministry of Education and Research (BMBF)
- German National Genome Research Network (NGFNplus) [01GS0834]
- University of Ulm
- Munich Center of Health Sciences (MC Health)
- Karl-Wilder Foundation
- German Diabetes Center
- German Federal Ministry of Health
- Ministry of Innovation, Science, Research and Technology of the State of North Rhine Westphalia
- Office of the Scottish Government
- Royal Society
- European Union [LSHG-CT-2006-018947]
- Academy of Finland [117797, 121584, 126925]
- Social Insurance Institution of Finland
- University Hospital Medical funds to Tampere
- Turku University Hospitals
- Finnish Foundation of Cardiovascular Research
- Austrian Science Fund (FWF) [P 20545] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710] Funding Source: researchfish
- Medical Research Council [MC_U127561128] Funding Source: researchfish
- MRC [MC_U127561128] Funding Source: UKRI
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Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 x 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.
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