Journal
NATURE GENETICS
Volume 43, Issue 11, Pages 1082-1090Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.941
Keywords
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Categories
Funding
- Academy of Finland [104781, 120315, 129269, 1114194]
- Center of Excellence in Complex Disease Genetics [213506, 129680]
- SALVE
- Althingi (Icelandic Parliament)
- Arthritis Research Campaign
- Asthma UK
- AstraZeneca
- AXA
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F019394/1, G20234]
- British Heart Foundation [PG/97012, PG/06/154/22043, FS05/125]
- British Lung Foundation
- Research United Kingdom
- Chief Scientist Office, Scottish Government Health Directorate [CZD/16/6]
- Croatian Institute for Public Health
- UK Department of Health
- Dutch Kidney Foundation
- Erasmus Medical Center and Erasmus University, Rotterdam
- Estonian Genome Center, University of Tartu, Estonia [SF0180142s08]
- EU [018996, QLK4-CT-1999-01237]
- European Commission [QLG1-CT-2000-01643, LSHB-CT-2006-018996, LSHG-CT2006- 01894, QLG2-CT-2002-01254, HEALTH-F2-2008-201865, HEALTH-F2-2008-35627, HEALTH-F4-2007-201413]
- Finnish Foundation for Cardiovascular Research
- Flight Attendant Medical Research Institute (FAMRI)
- German Asthma and COPD Network (COSYCONET: BMBF) [01GI0883]
- German Bundesministerium fuer Forschung und Technology [01 AK 803 A-H, 01 IG 07015 G]
- German Federal Ministry of Education and Research (BMBF)
- German National Genome Research Network
- German Ministry of Cultural Affairs
- GlaxoSmithKline
- Gyllenberg Foundations
- Healthway, Western Australia
- Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
- East Midlands Development Agency
- European Regional Development Fund
- Higher Education Funding Council for England (HEFCE)
- Hjartavernd (Icelandic Heart Association)
- Innsbruck Medical University
- Institute for Anthropological Research in Zagreb
- International Osteoporosis Foundation
- NIH, National Institute on Aging and National Institute of Environmental Health Sciences
- Jalmari and Rauha Ahokas Foundation
- Juvenile Diabetes Research Foundation International (JDRF)
- Lifelong Health and Wellbeing Initiative [G0700704/84698]
- Medical Research Council UK [G1000861, G0501942, G0902313, G0000934, G0800582, G0500539, G0600705, G9901462]
- Tampere University Hospital
- Ministry of Science, Education and Sport of the Republic of Croatia [108-1080315-0302]
- Medical Research Council Human Genetics Unit
- Medisearch-The Leicester Medical Research Foundation
- Munich Center of Health Sciences (MC Health) as part of LMUinnovativ
- National Health and Medical Research Council of Australia [ID 403981, ID 003209]
- National Human Genome Research Institute (NHGRI) [U01-HG-004729, U01-HG-004402]
- National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centres (Guy's & St. Thomas' NHS Foundation Trust
- King's College London and Cambridge University Hospitals NHS Foundation Trust
- University of Cambridge
- Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) [050-060-810]
- Netherlands Organization for the Health Research and Development (ZonMw)
- Netherlands Organization of Scientific Research NOW [1750102007006, 175.010.2005.011, 911-03-012]
- Northern Netherlands Collaboration of Provinces (SNN)
- Norwegian University of Science and Technology
- Novo Nordisk
- Ontario Institute of Cancer Research and Canadian Cancer Society Research Institute [CCSRI 020214]
- Republic of Croatia Ministry of Science, Education and Sports [108-1080315-0302]
- Research Institute for Diseases in the Elderly (RIDE) [014-93-015]
- Research Into Ageing [251]
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Structure Enhancing Fund (FES) of the Dutch government
- Swedish Heart and Lung Foundation [20050561]
- Swedish Research Council for Worklife and Social research (FAS) [2001-0263, 2003-0139]
- Swiss National Science Foundation [4026-28099, 3347CO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 32-65896.01, 32-59302.99, 32-52720.97, 32-4253.94]
- Asthma, Allergy and Inflammation Research Trust
- Great Wine Estates of the Margaret River region of Western Australia
- Netherlands' Ministry of Economic Affairs, Ministry of Education, Culture and Science and Ministry for Health, Welfare and Sports
- Royal Society
- University of Split and Zagreb Medical Schools
- Tromso University [U01 DK062418]
- UBS Wealth Foundation [BA29s8Q7-DZZ]
- University Hospital Oulu, Biocenter, University of Oulu, Finland [75617]
- University Medical Center Groningen
- University of Bristol
- University of Leicester
- University of Nottingham
- US National Institutes of Health (NIH) [1P50 CA70907, RO1 CA121197, U19 CA148127, CA55769, CA127219, R01HL071051, R01HL071205, R01HL071250, R01HL071251, R01HL071252, R01HL071258, R01HL071259, UL1RR025005, HHSN268200625226C, HHSN268200782096C, R01-HL084099]
- US NIH National Cancer Institute [RO1CA111703]
- US NIH National Center for Research Resources [M01-RR00425, 5M01 RR00997]
- US NIH National Eye Institute (NEI)
- US NIH National Heart, Lung and Blood Institute [N01-HC-85079, N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222]
- US NIH National Institute of Allergy and Infectious Diseases (NIAID)
- US NIH National Institute of Child Health and Human Development (NICHD)
- US NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [DK063491]
- US NIH National Institute of Environmental Health Sciences (NIEHS) [ZO1 ES49019, ES015794]
- US NIH National Institute of Mental Health (NIMH) [5R01MH63706: 02]
- US NIH National Institute of Neurological Disorders and Stroke (NINDD)
- US NIH National Institute on Aging (NIA) [R01 AG032098, RC1 AG035835, N01AG12100, N01AG62101, N01AG62103, N01AG62106, 1R01AG032098-01A1, AG-023269, AG-15928, AG-20098, AG-027058]
- Wellcome Trust [077016/Z/05/Z, GR069224, 068545/Z/02, 076113/B/04/Z, 079895]
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- British Heart Foundation [RG/08/013/25942] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710, CZD/16/6/2] Funding Source: researchfish
- Medical Research Council [G0800582, G0600705, MC_UP_A620_1015, G0700704B, G0801056, MC_U127561128, U1475000001, G0902313, MC_U123092720, MC_PC_U127561128, MC_U106188470, G1000861, G9815508, G0401540, G0501942, U1475000002, MC_U123092721, MC_UP_A620_1014, G0701863, G0801056B, G0000934, G0902125] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082] Funding Source: researchfish
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0600705, G0701863, MC_U123092721, G0000934, G0401540, G0501942, MC_U123092720, G0801056, MC_U127561128, MC_U106188470, G0902125, MC_PC_U127561128, G0800582, G1000861, MC_UP_A620_1015, G0902313] Funding Source: UKRI
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Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
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