Journal
NATURE GENETICS
Volume 43, Issue 4, Pages 345-U96Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.783
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Funding
- China National 863 Scientific Program [2006AA02Z476]
- China National Basic Research Program (973 program) [2007CB512002]
- Hubei Province Natural Science Key Program [2008CDA047]
- Key Academic Program Leader Award of Wuhan City [200951830560]
- National Natural Science Foundation of China [30670857, 30800457, 81070106]
- Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic
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Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 x 10(-3), stage 2 validation; P = 3.00 x 10(-3), P = 1.19 x 10(-8) and P = 4.00 x 10(-3) in three independent stage 3 replication populations; P = 4.87 x 10(-12), odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.
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