Journal
NATURE GENETICS
Volume 43, Issue 12, Pages 1215-U66Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.978
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Funding
- China National High-Tech Research and Development Program [2009AA022705, 2009AA022704, 2009AA022701]
- National Natural Science Foundation of China [30700684, 81130022, 30671814, 81001276, 81072380, 31000553]
- Jiangsu Natural Science Foundation [BK2008221]
- Foundation for the Author of National Excellent Doctoral Dissertation [201081, 201026]
- Program for New Century Excellent Talents in University [NCET-09-0550, NCET-10-0178]
- Jiangsu Higher Education Institutions (Public Health and Preventive Medicine)
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Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 x 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 x 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
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