Journal
NATURE GENETICS
Volume 43, Issue 4, Pages 329-U151Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.789
Keywords
-
Categories
Funding
- Isaac Newton Trust
- PBC Foundation
- Wellcome Trust [085925/Z/08/Z, WT090355/A/09/Z, WT090355/B/09/Z, WT91745/Z/10/Z]
- Raymond and Beverly Sackler Studentship
- US National Institutes of Health National Eye Institute [1RO1EY018246]
- NIHR comprehensive Biomedical Research Centre
- MRC [G0800460, G0802068, G0500020] Funding Source: UKRI
- Medical Research Council [G0800460, G0500020, G0802068] Funding Source: researchfish
- Wellcome Trust [085925/Z/08/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been identified in recent genome-wide association studies (GWAS). To identify additional loci, we carried out a GWAS using 1,840 cases from the UK PBC Consortium and 5,163 UK population controls as part of the Wellcome Trust Case Control Consortium 3 (WTCCC3). We followed up 28 loci in an additional UK cohort of 620 PBC cases and 2,514 population controls. We identified 12 new susceptibility loci (at a genome-wide significance level of P < 5 x 10(-8)) and replicated all previously associated loci. We identified three further new loci in a meta-analysis of data from our study and previously published GWAS results. New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available