Journal
NATURE GENETICS
Volume 44, Issue 1, Pages 58-U83Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.993
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Funding
- Heinz-Nixdorf Foundation
- German Centre for Neurodegenerative Disorders (DZNE), Bonn
- Myeloma UK
- Cancer Research UK [C1298/A8362]
- Bobby Moore Fund
- Leukaemia Lymphoma Research Fund
- National Health Services (NHS) through the Biological Research Centre of the National Institute for Health Research at the Royal Marsden Hospital NHS Trust
- APO-STS (European Union) [Health-F4-2007-200767]
- German Ministry of Education and Science
- German Research Council (DFG) [SI 236/8-1, SI236/9-1, ER 155/6-1]
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To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
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