Journal
NATURE GENETICS
Volume 43, Issue 4, Pages 289-290Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng0411-289
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New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
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