Journal
NATURE GENETICS
Volume 43, Issue 9, Pages 825-827Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.879
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Funding
- Cancer Research UK [C1298/A8362]
- DJ Fielding Medical Research Trust
- National Health Service (NHS)
- European Union [QLK4-CT-1999-01563]
- International Union against Cancer (UICC)
- Mobile Manufacturers' Forum and Global System for Mobile Communications Association
- Swedish Research Council
- Cancer Foundation of Northern Sweden
- Swedish Cancer Society
- Nordic Cancer Union
- Danish Cancer Society
- Mobile Telecommunications and Health Research (MTHR) Programme
- Health and Safety Executive
- Department of Health
- Safety Executive
- UK Network Operators
- Emil Aaltonen Foundation
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To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P-combined = 1.88 x 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
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