Journal
NATURE GENETICS
Volume 43, Issue 3, Pages 180-181Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng0311-180
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Follow-up studies of a Crohn's disease risk locus encompassing IRGM have revealed unexpected complexity. A new study shows that a synonymous variant in the IRGM coding region alters a binding site for miR-196 and modulates IRGM-dependent autophagy, adding to the list of possible mechanisms by which this locus influences disease risk.
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