Journal
NATURE GENETICS
Volume 42, Issue 10, Pages 864-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.660
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Funding
- Ministry of Education, Culture, Sports, Science and Technology Japan
- National Medical Research Council [NMRC/1115/2007]
- Korea Health 21 Research
- Development Project, Ministry of Health, Welfare
- Family Affairs, Republic of Korea [00-PJ3-PG6-GN07-001]
- Lundbeck Foundation Centre of Applied Medical Genomics for Personalized Disease Prediction, Prevention and Care (LuCAMP)
- European Union [LSHM-CT-2004-512013]
- EXGENESIS [LSHM-CT-2004-005272]
- Danish Diabetes Association
- Danish Agency for Science, Technology and Innovation [271-06-0539]
- MRC [G0600331, G0501184] Funding Source: UKRI
- Medical Research Council [G0600331, G0501184] Funding Source: researchfish
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We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 x 10(-9); rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 x 10(-9)). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 x 10(-14), whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.
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