Journal
NATURE GENETICS
Volume 42, Issue 3, Pages 197-199Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.532
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Funding
- BHF
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [G20234]
- Dutch Kidney Foundation [E033]
- Netherlands Heart Foundation [2006B140, 2006T003]
- EU [FP-6 LSHM CT 2006 037697]
- Leicester National Institute of Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease
- NIHR Biomedical Research Centre
- Netherlands Organisation for Scientific Research (NWO) VENI [916.76.170]
- Interuniversity Cardiology Institute of the Netherlands (ICIN)
- European Network for Genetic and Genomic Epidemiology (ENGAGE) [HEALTH-F4-2007-201413]
- MRC [G0501942] Funding Source: UKRI
- Medical Research Council [G0501942] Funding Source: researchfish
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We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an similar to 75-base-pair reduction in mean telomere length, equivalent to similar to 3.6 years of age-related telomere-length attrition.
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