Journal
NATURE GENETICS
Volume 42, Issue 3, Pages 200-202Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.535
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Funding
- US National Institutes of Health (NIH) [R01 HL075478, R01 HL084323, P01 HL083069, U01 HL089856, K12HL089990, U01 HL089897]
- National Heart, Lung, and Blood Institute
- Centers for Medicare and Medicaid Services
- Agency for Healthcare Research and Quality
- US Department of Veterans Affairs
- GlaxoSmithKline
- MRC [G0500306] Funding Source: UKRI
- Medical Research Council [G0500306] Funding Source: researchfish
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We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).
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