Journal
NATURE GENETICS
Volume 42, Issue 9, Pages 772-U63Publisher
NATURE PORTFOLIO
DOI: 10.1038/ng.640
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Funding
- Wellcome Trust (UK) [085475]
- Agency for Science and Technology and Research of Singapore (A*STAR) (Singapore)
- Meningitis Research Foundation (UK)
- European Society for Pediatric Infectious Diseases
- Oesterreichische Nationalbank (Austria) [8842, 10112, 12710]
- Department for Science and Research of the Styrian federal government (Austria) [A3-16.K-8/2008-11, A3-16.K-8/2006-9]
- 'In Vita', Graz (Austria)
- Xunta de Galicia [PGIDIT06PXIB208079PR, 2008/037]
- Fundacion de Investigacion Medica Mutua Madrilena [2008/CL444]
- Ministerio de Ciencia e Innovacion [SAF2008-02971]
- Conselleria de Sanidade (Xunta de Galicia) [RHI07/2]
- Instituto Carlos III (Intensificacion de la actividad investigadora)
- Convenio de colaboracion de investigacion (Wyeth Espana-Fundacion)
- Fondo de Investigacion Sanitaria (FIS) [PI070069]
- Fondos FEDER
- Erasmus MC Revolving Fund Foundation (The Netherlands) [RF 2001/24]
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Meningococcal disease is an infection caused by Neisseria meningitidis. Genetic factors contribute to host susceptibility and progression to disease, but the genes responsible for disease development are largely unknown(1-3). We report here a genome-wide association study for host susceptibility to meningococcal disease using 475 individuals with meningococcal disease (cases) and 4,703 population controls from the UK. We performed, in Western European and South European cohorts (consisting of 968 cases and 1,376 controls), two replication studies for the most significant SNPs. A cluster of complement factor SNPs replicated independently in both cohorts, including SNPs within complement factor H (CFH) (rs1065489 (p.936D
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