Journal
NATURE GENETICS
Volume 42, Issue 9, Pages 733-734Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng0910-733
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK077822, R01DK046865] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK077822, R01 DK077822-04, R01 DK046865, R01 DK046865-18] Funding Source: Medline
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The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.
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