Journal
NATURE GENETICS
Volume 43, Issue 1, Pages 60-U83Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.723
Keywords
-
Categories
Funding
- French Institut National du Cancer (INCa)
- National Cancer Institute (NCI), US National Institutes of Health (NIH)
- Cancer Research UK [11021, 11022, 10118] Funding Source: researchfish
- Medical Research Council [G0401527, G1000143, G0801056B] Funding Source: researchfish
- The Francis Crick Institute [10124, 10119] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [ZIACP010201] Funding Source: NIH RePORTER
Ask authors/readers for more resources
We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10(-8)) and rs7579899 (P = 2.3 x 10(-9)), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(-14)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10(-8)). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available