Journal
NATURE GENETICS
Volume 42, Issue 8, Pages 665-667Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.620
Keywords
-
Categories
Funding
- Dutch Organization for Scientific Research (NWO) [92003420]
- Stichting Vanderes [07-183]
Ask authors/readers for more resources
In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available