4.8 Article

Common variants in FOXP1 are associated with generalized vitiligo

Journal

NATURE GENETICS
Volume 42, Issue 7, Pages 576-578

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ng.602

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Funding

  1. Vitiligo Support International
  2. Vitiligo Society
  3. National Vitiligo Foundation
  4. American Vitiligo Research Foundation
  5. Associazione Ricerca Informazione per la Vitiligine
  6. US National Institutes of Health [AR45584, AR056292]

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In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 x 10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 x 10(-7)).

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