Journal
NATURE GENETICS
Volume 42, Issue 2, Pages 132-U59Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.510
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Funding
- Leukaemia Research Fund [LRF05001, 06002]
- CLL Global Research Foundation
- Cancer Research UK [C1298/A8362]
- Arbib Fund
- Institute of Cancer Research. Funding
- Wellcome Trust [076113, 085475]
- UK, National Health Service
- Insituto de Salud Carlos III [SAF 08/3630]
- Xunta de Galicia [PGIDIT 08CSA005208PR]
- Spanish National Genotyping Center
- Medical Research Council [G0000934, MC_U132670597] Funding Source: researchfish
- MRC [G0000934, MC_U132670597] Funding Source: UKRI
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To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
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