Journal
NATURE GENETICS
Volume 42, Issue 11, Pages 973-U89Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.670
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Funding
- Cancer Research UK
- Oxford Comprehensive Biomedical Research Centre
- EU
- Core infrastructure
- Centre for Human Genetics, Oxford [075491/Z/04]
- Medical Research Council [G0000657-53203]
- CORE and Scottish Executive Chief Scientist's Office [K/OPR/2/2/D333, CZB/4/449]
- Cancer Research UK [C31250/A10107]
- Cancer Research Wales, Tenovus and Wales Gene Park
- Academy of Finland
- Finnish Cancer Society
- Sigrid Juselius Foundation
- MRC [MC_U122861325, MC_U127527198, G0301096] Funding Source: UKRI
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
- Chief Scientist Office [CZB/4/449] Funding Source: researchfish
- Medical Research Council [MC_U122861325, MC_U127527198, G0301096] Funding Source: researchfish
- Tenovus Cancer Care [PhD2009/L27] Funding Source: researchfish
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Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 x 10(-10) and rs6687758, OR = 1.09, P = 2.27 x 10(-9)), 3q26.2 (rs10936599, OR = 0.93, P = 3.39 x 10(-8)), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 x 10(-10) and rs7136702, OR = 1.06, P = 4.02 x 10(-8)) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 x 10(-10)). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.
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