Journal
NATURE GENETICS
Volume 41, Issue 4, Pages 396-398Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.321
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Funding
- NHLBI, GSK Research & Education Foundation Cardiovascular Awards [K08]
- NWO VIDI
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Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
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