Journal
NATURE GENETICS
Volume 41, Issue 6, Pages 677-687Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.384
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCRR NIH HHS [UL1 RR025005-01, UL1RR025005, UL1 RR025005] Funding Source: Medline
- NHGRI NIH HHS [U01 HG004402-01, U01 HG004402, U01HG004402] Funding Source: Medline
- NHLBI NIH HHS [U10 HL054512, R01HL086694, N01-HC-55019, N01HC55019, N01 HC055018, N01-HC-85085, N01HC55018, N01-HC-55016, N01HC75150, R01 HL059367-02, R01 HL059367, R37 HL051021-11, N01-HC-85083, N01HC55016, N01-HC-85081, N01-HC-55022, N01-HC-85082, N01 HC055019, N02-HL-6-4278, N01-HC-25195, N01 HC055022, N01 HC085086, N01-HC-75150, N01-HC-55020, N01-HC-85080, N01HC55020, N01 HC055021, R37HL051021, R01HL087641, N01 HC075150, N01-HC-85084, N01HC85086, U10 HL054512-05, N01-HC-55015, N01 HC055222, N01 HC-55222, N01HC55015, R37 HL051021-14, N01 HC045133, U01 HL080295, R37 HL051021-15, R37 HL051021-10, N01 HC035129, R37 HL051021, N01 HC055016, N01HC25195, N01 HC025195, R01 HL086694, R37 HL051021-06, N01 HC055015, U01 HL080295-01, R01 HL087641-01, N01-HC-85079, N02 HL64278, N01 HC055020, R01 HL087652-01, R37 HL051021-12, R01 HL087652, N01HC55022, R01HL59367, R01 HL086694-01A1, U10HL054512, N01-HC-55018, N01HC55021, N01HC85079, N01 HC085079, R01 HL087641, N01-HC-85086, R37 HL051021-13, N01-HC-55021, N01HC55222, N01 HC015103] Funding Source: Medline
- NIA NIH HHS [N01AG12100, N01 AG012100] Funding Source: Medline
- NIDDK NIH HHS [P30 DK063491-029004, P30 DK063491, P30 DK063491-039004, P30 DK063491-019004, P30 DK063491-049004] Funding Source: Medline
- PHS HHS [HHSN268200625226C] Funding Source: Medline
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Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 x 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 x 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.
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