Journal
NATURE GENETICS
Volume 41, Issue 3, Pages 280-282Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.307
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Funding
- British Heart Foundation Funding Source: Medline
- Medical Research Council Funding Source: Medline
- NCRR NIH HHS [U54RR020278, U54 RR020278] Funding Source: Medline
- NHLBI NIH HHS [R01HL087676, R01 HL056931-04, R01 HL056931-03, R01 HL056931-02, R01 HL087676] Funding Source: Medline
- Wellcome Trust [076113, 089061, 077011] Funding Source: Medline
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We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
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