Journal
NATURE GENETICS
Volume 41, Issue 12, Pages 1335-U107Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.489
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Funding
- Children's Hospital of Philadelphia
- Primary Children's Medical Center Foundation
- National Center for Research Resources [DK069513, M01-RR00064, M01 RR002172-26, C06-RR11234]
- NIH/NIDDK [DK062423]
- Gale and Graham Wright Research Chair in Digestive Diseases
- Canadian Association of Gastroenterology (CAG)
- Crohn's Colitis Foundation of Canada (CCFC)
- Canadian Institutes of Health Research (CIHR)
- Astra-Zeneca
- CCFC/CAG/CIHR Transition Award
- Canadian Child Health Clinician Scientist Program (CCHCSP)
- Children's Hospital Boston
- NIDDK [DK069513, T32 DK007477]
- NCRR [M01-RR00064, C06-RR11234]
- Action Medical Research
- Gay-Ramsay-SteelMaitland or Stafford Trust
- Hazel M Wood Charitable Trust
- Medical Research Council Patient Cohorts Research Initiative award [G0800675]
- Wellcome Trust Programme Grant [072789/Z/03/Z]
- Chief Scientist Office of the Scottish Government Health Department
- University of Edinburgh Medical Faculty Fellowship
- GI/Nutrition Research Fund
- Child Life and Health
- University of Edinburgh
- MRC [G0800759, G0800675, G0600329] Funding Source: UKRI
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0800675, G0800759, G0600329] Funding Source: researchfish
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The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD1. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
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