Journal
NATURE GENETICS
Volume 42, Issue 1, Pages 45-U61Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.500
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Funding
- Intramural NIH HHS [ZIA ES043012-11, Z01 ES043012] Funding Source: Medline
- Medical Research Council [G0000934] Funding Source: Medline
- NCRR NIH HHS [M01 RR000425, M01-RR00425] Funding Source: Medline
- NHGRI NIH HHS [U01HG004402, U01 HG004402] Funding Source: Medline
- NHLBI NIH HHS [R01HL59367, R01HL086694, N01HC55016, N01-HC-55022, N01HC55018, N01-HC-55019, N01HC55020, N01-HC-75150, N01-HC-85079 THROUGH N01-HC-85086, R01 HL087652, N01HC55022, N01HC55222, N01-HC-55021, N01HC85086, R01 HL087641, N01HC55021, N01-HC-55018, N01HC85079, N01-HC-25195, N02-HL-6-4278, U01 HL080295, N01 HC-55222, N01-HC-55016, N01HC55015, N01HC55019, R01 HL077612, N01HC75150, N01-HC-55020, R01 HL059367, N01HC25195, N01-HC-55015, R01HL087641, R01 HL086694, RC1 HL100543] Funding Source: Medline
- NIDDK NIH HHS [P30 DK063491, DK063491] Funding Source: Medline
- PHS HHS [HHSN268200625226C] Funding Source: Medline
- MRC [G0000934] Funding Source: UKRI
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC025195, N01HC075150, N01HC055015, N01HC055019, N01HC095159, N01HC055222, N01HC055021, N01HC055020, N01HC055018, N01HC055022, N01HC085079, N01HC055016, N01HC035129, N01HC045133, N01HC015103] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000425] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R41HL055019, R01HL087641, R01HL059367, R01HL087652, R01HL086694, R42HL055018, RC1HL100543, R01HL064278, R41HL055018, U01HL080295, R01HL077612] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG004402] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK063491] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES043012, Z01ES043012] Funding Source: NIH RePORTER
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Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV1/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.
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